diff --git a/Doc/library/profiling.sampling.rst b/Doc/library/profiling.sampling.rst
index aeb1a429b58515a..39b6ea4e31cde72 100644
--- a/Doc/library/profiling.sampling.rst
+++ b/Doc/library/profiling.sampling.rst
@@ -387,6 +387,11 @@ This requires one of:
 On Windows, the profiler requires administrative privileges or the
 ``SeDebugPrivilege`` privilege to read another process's memory.
 
+*Note*: On Windows, ``python -m profiling.sampling`` fails inside a virtual
+environment because the venv's ``python.exe`` is just a launcher shim that
+re-executes the base interpreter as a child process. The shim itself isn't
+a Python process and has no ``PyRuntime`` section to attach to. Instead,
+run it from the global Python installation.
 
 Version compatibility
 ---------------------